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Title
Author
Date of Award
2015
Degree Type
Dissertation
Degree Name
Ph.D.
Department
Communication
First Advisor
Kimmi Nakajima
Abstract
This dissertation is an investigation of a highly visual, interactive, and gamified form of rhetoric (that is, persuasive writing and argumentation) for learning about science. The dissertation challenges the long held belief that discourse analysis can be accomplished by studying source material from a purely textual analysis point of view, and instead proposes that it should be studied through an analysis of the various ways that evidence is put to use through the creation of persuasive writing.Inhibition of human high-mobility group box 1 protects against early acute lung injury induced by endotoxin.
Acute lung injury (ALI) is a fatal lung disease with high mortality and high morbidity. High-mobility group box 1 (HMGB1) has been shown to be involved in the pathophysiology of ALI. HMGB1 is a ubiquitous nuclear protein that is actively exported to the cytosol, and functions as a versatile cytokine. Despite the accumulating data, the role of HMGB1 in the development of ALI remains poorly defined. Our present study firstly proved that HMGB1 release is increased in human endothelial cells in vitro after LPS stimulation. The administration of anti-HMGB1 neutralizing antibody in endotoxin-induced septic mice reduced the release of HMGB1 in serum and lung tissues, and decreased the level of inflammatory cytokines in the bronchoalveolar lavage fluid. The treatment of anti-HMGB1 neutralizing antibody also reduced lung edema and improved the survival rate of the mice. Furthermore, in vivo treatment of anti-HMGB1 neutralizing antibody dramatically reduced the number of infiltrated neutrophils, but increased the number of macrophages in the lung tissue. Taken together, our results indicate that the inhibition of HMGB1 can provide a novel approach to ALI.Strikingly green iridescence in the visual ecology of juvenile green turtle juveniles in the Florida Keys.
Green turtles (Chelonia mydas) are iconic marine animals, but their visual ecology is largely unknown. Here we show that green turtle hatchlings in the Florida Keys, USA, display striking iridescent coloration, including distinctive green backgrounds and be359ba680
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