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A: The production and repair of oxidized DNA. In order to protect DNA from oxidative damage, the cell has developed a complex defence system that includes enzymes that repair damaged bases, and proteins that target and process oxidized bases. Mammalian cells have evolved several pathways to repair oxidized DNA. In eukaryotic cells, the base excision repair pathway and its derivatives play a major role in the repair of oxidized DNA. Base excision repair removes a damaged base using a DNA glycosylase, the repair enzyme apurinic/apyrimidinic endonuclease, and DNA polymerase, β. DNA repair by base excision repair involves an ATP-dependent reaction and the concomitant incision of the oxidized base. The DNA excision repair system is also implicated in the removal of hydrogen peroxide-induced DNA damage by several lines of evidence. The principal proteins involved in DNA excision repair in mammalian cells include the apurinic/apyrimidinic endonuclease-1, DNA polymerase β, the apurinic/apyrimidinic endonuclease-1, flap endonuclease 1 and polynucleotide kinase 3′-phosphatase. In mammalian cells, the most important role of base excision repair is to repair endogenous oxidative lesions caused by free radicals generated endogenously or ingested from the environment.Wedding Dresser The Heart of a Good Wedding Dresser Is The Luxurious Range Of Accessories You Can Store In It Getting ready for the big day of your life is a time when you need to look your best. However, if you’re without much budget and don’t have a lot of space for all the things that you’ll need to use for your wedding, you might be feeling overwhelmed with everything. While it’s a very important day in your life and you need to have it the best way possible, this also doesn’t mean that you have to spend an arm and a leg just to look perfect. Fortunately, there is a way to achieve perfection without breaking the bank. There are numerous things that you can keep in your dresser that will help you look your best and can also save you a lot of money. Here are just a few of them: If you ac619d1d87

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